IGN puts forth its list. My thoughts on the ones I've played or been familiar with:

#100 River City Ransom
The only thing I really remember about this game is its similarity to... Double Dragon, I think? Maybe something else. I remember playing it, but I don't remember the features they were talking about. They were probably lost on me.

#097 - F-Zero
This is the ultimate reverse-drinking video game. Ordinarily you take a drink when you lose, but in this one it would be best to take one when you win. The courses were so tough and unforgiving that driving drunk was a very dangerous proposition. I only got to do the drinking game thing once on it, which makes me wonder if I wasted too much time in my younger years around sober people.

#093 - Quake II
I still play this game regularly. I know the levels extremely well and can bust through it pretty quickly in God-Mode. It's invaluable when one is pissed off at the rest of the world and ready to start busting (or blowing off) some heads.

#083 - Contra
I was a bit surprised to see this one on there. Not because it wasn't a really good game, but because I don't remember it being as 'revolutionary' as they seem to (and I should defer to their perspective, they're much more into it than I). The simultaneous two-player mode was pretty cool, though. I always thought it odd that Mario Brothers never did that.

#083 Baseball Stars
I never actually played this one. Extremely generic-looking stuff, but apparently it has team creation! How did I not know that this game existed? Probably because it was so generic looking.

#074 - Syndicate
I had this one on my old Amiga 500. It was an amazingly complex game for its time. Too complex for me, actually, because I didn't have the time to devote to it. But even now I'm impressed by what that game was able to deliver.


#058 - Super Smash Bros. Melee
I don't have a Gamecube, but this one would look awfully cool if I did.

#057 - Mike Tyson's Punchout
I will probably remember and mention Mike Tyson more in conjunction to this game than his floundering boxing career. It's one of the only NES games that I still find myself talking about. I remember when I finally beat Soda Popinsky and I literally jumped up and started dancing around. I forgot to let go of the remote and pulled the system out from the power supply, turning the game off.

#054 - Panzer Dragoon Saga
The game that I never played and yet had a profound effect on my life. The introduction to the game alone was impressive. Watching other people play the game was also worthwhile.

#046 - Super Mario World
I had tons of fun playing the ROM. When I eventually got the SNES, I never really played in on that in part because it didn't offer 'save state.' The same happened to the SNES version of Zelda.

#040 - VirtuaFighter 4 Evolution
I never played Evolution, but I was always really impressed with the whole series. It was the only fighting game I couldn't cheat at and it didn't rely on special moves as much as the others.

#039 - Doom
I wanna play it again some time. Soon. I doubt it'll be nearly as impressive as it was (or as Quake II is), but still.

#034 - Tony Hawk's Pro Skater 2
I've seen others play variations of this game, though I really do think they should add a helmetless crack.

#031 - SimCity 2000
The original was a classic. SC2K looked good, but more complicated, so I never really got around to it.

#024 - Tecmo Superbowl
I love this game. I hate this game.

#023 - Super Mario Bros. 3
It was a definite improvement over the first two in most respects, but I was ultimately disappointed. While the 'teamwork' aspect of it was nice, I was surprised that they never came up with simultaneous play. As a Luigi fan, I was also disappointed that they did away with the ability to select Luigi (or the Princess or Toad) - a step backwards.

#015 - Super Mario Kart
Absolutely! Fun, exciting, and addicting. Funnest multi-player game ever, in my estimation.

#011 - Legend of Zelda: A Link to the Past
Like Super Mario World, this was mostly a ROM game for me. I can't imagine playing it any other way. Save State saved my butt. Very solid game, but... [see below]

#005 - Super Mario 64
To the detriment of my relationship at the time, I have played this game from top to bottom and it is very worthy of its place on this list. Even after you've solved it, it's still just fun to run around.

#003 - Tetris
No argument here, but where's Minesweeper?

#002 - Legend of Zelda: Ocarina of Time
I've heard nothing but great things about it, but... [read below]

#001 - Super Mario Bros.
I salivated over the NES for years because of this game. It doesn't hold up as well as some of the others, but it inspired half of the stuff that does hold up!

Here are the ones I'm a little surprised to not see on the list.

Legend of Zelda (NES)
This game was huge! No disrespect to the Zelda games that did get mentioned, but how is this one not on the list. I can't believe the list could have overlooked this one.

Baseball Simulator 1.000 (NES)
Like Mario Kart, it took a pretty straight concept and added a fun dimension. While RBI and the like strived and fell short of realism, BS1K was just a fun game.

Bases Loaded (NES)
Where a lot of baseball games fell short, this one succeeded. You couldn't make your own teams or anything, but you did have full season play (didn't it?)

Adventure (Atari 2600)
Yeah, you're just a huge pixel, but the Atari 2600 produced absolutely nothing else like it! Okay, it's a stretch, but still...